NAD+ Research


NAD+ also known as Nicotinamide Adenine Dinucleotide is a cofactor found in all living cells. NAD+ is an important carrier of electrons and hydrogen for the cell and is crucial for the ongoing production of energy by the mitochondria. In fact NAD+ helps to fuel over 400 metabolic reactions.

It has been demonstrated that NAD+ availability decreases over age, reducing sirtuin activities and affecting the communication between the nucleus and mitochondria at a cellular level and also between the hypothalamus and adipose tissue at a systemic level. These dynamic cellular and systemic processes likely contribute to the development of age-associated functional decline and the pathogenesis of diseases of aging. - NAD+ and sirtuins in aging/longevity control. NPJ Aging Mech Dis. 2016;2:16017. 

NAD+ was discovered in 1906 and labelled the "Youth Molecule". Recent studies have discovered that as we age, the NAD+ level in our cells gradually decrease. This can be by as much as 50% by the team we reach the age of 60. Elevating NAD+ through supplementation may help to alleviate symptoms of aging restoring youthful health and vitality.

Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that serves as an essential cofactor and substrate for a number of critical cellular processes involved in oxidative phosphorylation and ATP production, DNA repair, epigenetically modulated gene expression, intracellular calcium signaling, and immunological functions. Recent studies have shown that enhancing NAD+ levels can profoundly reduce oxidative cell damage in catabolic tissue, including the brain. Therefore, promotion of intracellular NAD+ anabolism represents a promising therapeutic strategy for age-associated degenerative diseases in general, and is essential to the effective realization of multiple benefits of healthy sirtuin activity. - Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes. Antioxidants and Redox Signaling 30(2)

NAD+ when produced naturally helps to increase DNA damage repair, improves cognitive function, boosts oxidative stress resistance, restores energy levels and helps to reduce inflammation.